Glossary

A
ABDOMEN/ABDOMINAL
Body cavity below diaphragm that contains stomach, intestines, liver and other organs
ABSORB
take up fluids, take in
ACIDOSIS
Condition when blood contains more acid than normal
ACUITY
Clearness, keenness, esp. of vision and airways
ACUTE
New, recent, sudden, urgent
ADENOPATHY
Swollen lymph nodes (glands)
ADHD
The abbreviation for attention deficit hyperactivity disorder
ADJUVANT
Helpful, assisting, aiding, supportive
ADJUVANT TREATMENT
Added treatment (usually to a standard treatment)
ADVERSE EFFECT
Side effect, bad reaction, unwanted response
ALLERGIC REACTION
Rash, hives, swelling, trouble breathing
AMBULATE/ AMBULATION/ AMBULATORY
Walk, able to walk
ANAPHYLAXIS
Serious, potentially life-threatening allergic reaction
ANEMIA
Decreased red blood cells; low red cell blood count
ANESTHETIC
A drug or agent used to decrease the feeling of pain, or eliminate the feeling of pain by putting you to sleep
ANEURYSMS
Caused by dilation of a blood vessel, and can lead to rupture and death.
ANGINA
Pain resulting from not enough blood flowing to the heart
ANGINA PECTORIS
Pain resulting from not enough blood flowing to the heart
ANGIOEDEMA
The swelling of the deeper layers of the skin, caused by a build-up of fluid.
ANOREXIA
Disorder in which person will not eat; lack of appetite
ANTECUBITAL
Related to the inner side of the forearm
ANTIBIOTIC
Drug that kills bacteria and other germs
ANTIBODY
Protein made in the body in response to foreign substance
ANTICONVULSANT
Drug used to prevent seizures
ANTILIPEMIC
A drug that lowers fat levels in the blood
ANTIMICROBIAL
Drug that kills bacteria and other germs
ANTIRETROVIRAL
Drug that works against the growth of certain viruses
ANTITUSSIVE
A drug used to relieve coughing
AORTA
The largest artery in the body
ARRHYTHMIA
Abnormal heartbeat; any change from the normal heartbeat
ASPIRATION
Fluid entering the lungs, such as after vomiting
ASSAY
Lab test
ASSESS
To learn about, measure, evaluate, look at
ASTHMA
Lung disease associated with tightening of air passages, making breathing difficult
ASYMPTOMATIC
Without symptoms
AUTOIMMUNE DISEASE
A problem with the body’s immune system, when it starts to attack healthy cells, tissues and organs. Examples include lupus and rheumatoid arthritis
AXILLA
Armpit
B
BARIATRIC SURGERY
Surgery for weight loss, such as gastric bypass surgery or gastric band
BENIGN
Not malignant, without serious consequences
BID
Twice a day
BINDING/BOUND
Carried by, to make stick together, transported
BIOAVAILABILITY
The extent to which a drug or other substance becomes available to the body
BIOPSY
A sample of cells or tissue is removed from the body and tested to help exclude or establish a diagnosis such as cancer
BLOOD PROFILE
Series of blood tests
BOLUS
A large amount given all at once
BONE MASS
The amount of calcium and other minerals in a given amount of bone
BRACHYTHERAPY
A cancer treatment whereby radioactive material is inserted directly into the tumor
BRADYARRHYTHMIAS
Slow, irregular heartbeats
BRADYCARDIA
Slow heartbeat
BRONCHOSCOPY
Examination of the airways using a bronchoscope (a flexible or rigid tube with a small camera and light at the end)
BRONCHOSPASM
Breathing distress caused by narrowing of the airways
C
CARDIAC ARREST
A cessation of the normal regular muscular contractions of the heart, meaning blood cannot be pumped around the body
CARDIOVERSION
Return to normal heartbeat by electric shock
CATHETER
A tube for withdrawing or giving fluids
CATHETER
A tube placed near the spinal cord and used for anesthesia (indwelling epidural) during surgery
CENTRAL NERVOUS SYSTEM (CNS)
Brain and spinal cord
CEREBRAL TRAUMA
Damage to the brain
CESSATION
Stopping
CHD
Stopping
CHEMOTHERAPY
Treatment of disease, usually cancer, by chemical agents
CHRONIC
Continuing for a long time, ongoing
CLINICAL
Pertaining to medical care
CLINICAL TRIAL
An experiment involving human subjects
COMA
Unconscious state
COMPLETE RESPONSE
Total disappearance of disease
CONGENITAL
Present before birth
CONJUNCTIVITIS
Redness and irritation of the thin membrane that covers the eye
CONSOLIDATION PHASE
Treatment phase intended to make a remission permanent (follows induction phase)
CONTROLLED TRIAL
Research study in which the experimental treatment or procedure is compared to a standard (control) treatment or procedure
COOPERATIVE GROUP
Association of multiple institutions to perform clinical trials
CORONARY
Related to the blood vessels that supply the heart, or to the heart itself
CT SCAN (CAT)
Computerized series of x-rays (computerized tomography)
CULTURE
Test for infection, or for organisms that could cause infection
CUMULATIVE
Added together from the beginning
CUTANEOUS
Relating to the skin
CVA
Stroke (cerebrovascular accident)
D
DERMATOLOGIC
Pertaining to the skin
DIASTOLIC
Lower number in a blood pressure reading
DISTAL
Toward the end, away from the center of the body
DIURETIC
“Water pill” or drug that causes increase in urination
DOPPLER
Device using sound waves to diagnose or test
DOUBLE BLIND
Study in which neither investigators nor subjects know what drug or treatment the subject is receiving
DYSFUNCTION
State of improper function
DYSPLASIA
Abnormal cells
E
ECHOCARDIOGRAM
Sound wave test of the heart
EDEMA
Excess fluid collecting in tissue
EEG
Electric brain wave tracing (electroencephalogram)
EFFICACY
Effectiveness
ELECTROCARDIOGRAM
Electrical tracing of the heartbeat (ECG or EKG)
ELECTROLYTE IMBALANCE
An imbalance of minerals in the blood
EMESIS
Vomiting
EMPIRIC
Based on experience
ENDOSCOPIC EXAMINATION
Examination of an internal part of the body with a lighted tube ENTERAL by way of the intestines
EPIDURAL
Outside the spinal cord
ERADICATE
Get rid of (such as disease)
EVALUATED, ASSESSED
Examined for a medical condition
EXPEDITED REVIEW
Rapid review of a protocol by the IRB Chair without full committee approval, permitted with certain low-risk research studies
EXTERNAL
Outside the body
EXTRAVASATE
To leak outside of a planned area, such as out of a blood vessel
F
FDA
U.S. Food and Drug Administration, the branch of federal government that approves new drugs
FIBRILLATION
Irregular beat of the heart or other muscle
FIBROUS
Having many fibers, such as scar tissue
G
GENERAL ANESTHESIA
Pain prevention by giving drugs to cause loss of consciousness, as during surgery
GESTATIONAL
Pertaining to pregnancy
H
HEMATOCRIT
Amount of red blood cells in the blood
HEMATOMA
A bruise, a black and blue mark
HEMODYNAMIC MEASURING
Measuring of blood flow
HEMOLYSIS
Breakdown in red blood cells
HEPARIN LOCK
Needle placed in the arm with blood thinner to keep the blood from clotting
HEPATOMA
Cancer or tumor of the liver
HERITABLE DISEASE
Disease that can be transmitted to one’s offspring, resulting in damage to future children
HISTOPATHOLOGIC
Pertaining to the disease status of body tissues or cells
HOLTER MONITOR
A portable machine for recording heart beats
HYPERCALCEMIA
High blood calcium level
HYPERKALEMIA
High blood potassium level
HYPERNATREMIA
High blood sodium level
HYPERTENSION
High blood pressure
HYPOCALCEMIA
Low blood calcium level
HYPOKALEMIA
Low blood potassium level
HYPONATREMIA
Low blood sodium level
HYPOTENSION
Low blood pressure
HYPOXEMIA
A decrease of oxygen in the blood
HYPOXIA
A decrease of oxygen reaching body tissues
HYSTERECTOMY
Surgical removal of the uterus, ovaries (female sex glands), or both uterus and ovaries
I
IATROGENIC
Caused by a physician or by treatment
IDE
Investigational device exemption, the license to test an unapproved new medical device
IDIOPATHIC
Of unknown cause
IMMUNITY
Defense against, protection from
IMMUNOGLOBIN
A protein that makes antibodies
IMMUNOSUPPRESSIVE
Drug which works against the body’s immune (protective) response, often used in transplantation and diseases caused by immune system malfunction
IMMUNOTHERAPY
Giving of drugs to help the body’s immune (protective) system; usually used to destroy cancer cells
IMPAIRED FUNCTION
Abnormal function
IMPLANTED
Placed in the body
IND
Investigational new drug, the license to test an unapproved new drug
INDUCTION PHASE
Beginning phase or stage of a treatment
INDURATION
Hardening
INDWELLING
Remaining in a given location, such as a catheter
INFARCT
Death of tissue due to lack of blood supply
INFECTIOUS DISEASE
Disease that is transmitted from one person to the next
INFLAMMATION
Swelling that is generally painful, red, and warm
INFUSION
Slow injection of a substance into the body, usually into the blood by means of a catheter
INGESTION
Eating; taking by mouth
INTERFERON
Drug which acts against viruses; antiviral agent
INTERIOR
Inside of the body
INTERMITTENT
Occurring (regularly or irregularly) between two time points; repeatedly stopping, then starting again
INTERNAL
Within the body
INTRAMUSCULAR
Into the muscle; within the muscle
INTRAPERITONEAL
Into the abdominal cavity
INTRATHECAL
Into the spinal fluid
INTRAVENOUS (IV)
Through the vein
INTRAVESICAL
In the bladder
INTUBATE
The placement of a tube into the airway
INVASIVE PROCEDURE
Puncturing, opening, or cutting the skin
INVESTIGATIONAL METHOD
A treatment method which has not been proven to be beneficial or has not been accepted as standard care
INVESTIGATIONAL NEW DRUG (IND)
A new drug that has not been approved by the FDA
ISCHEMIA
Decreased oxygen in a tissue (usually because of decreased blood flow)
L
LAPAROTOMY
Surgical procedure in which an incision is made in the abdominal wall to enable a doctor to look at the organs inside
LESION
Wound or injury; a diseased patch of skin
LETHARGY
Sleepiness, tiredness
LEUKOPENIA
Low white blood cell count
LIPID
Fat
LIPID CONTENT
Fat content in the blood
LIPID PROFILE (PANEL)
Fat and cholesterol levels in the blood
LOCAL ANESTHESIA
Creation of insensitivity to pain in a small, local area of the body, usually by injection of numbing drugs
LOCALIZED
Restricted to one area, limited to one area
LUMEN
The cavity of an organ or tube (e.g., blood vessel)
LYMPHANGIOGRAPHY
An x-ray of the lymph nodes or tissues after injecting dye into lymph vessels (e.g., in feet)
LYMPHOCYTE
A type of white blood cell important in immunity (protection) against infection
LYMPHOMA
A cancer of the lymph nodes (or tissues)
M
MALAISE
A vague feeling of bodily discomfort, feeling badly
MALFUNCTION
Condition in which something is not functioning properly
MALIGNANCY
Cancer or other progressively enlarging and spreading tumor, usually fatal if not successfully treated
MEDULLABLASTOMA
A type of brain tumor
MEGALOBLASTOSIS
Change in red blood cells
METABOLIZE
Process of breaking down substances in the cells to obtain energy
METASTASIS
Spread of cancer cells from one part of the body to another
METRONIDAZOLE
Drug used to treat infections caused by parasites (invading organisms that take up living in the body) or other causes of anaerobic infection (not requiring oxygen to survive)
MINIMAL
Slight
MINIMIZE
Reduce as much as possible
MOBILITY
Ease of movement
MONITOR
Check on; keep track of; watch carefully
MORBIDITY
Undesired result or complication
MORTALITY
Death
MOTILITY
The ability to move
MRI
Magnetic resonance imaging, diagnostic pictures of the inside of the body, created using magnetic rather than x-ray energy
MUCOSA, MUCOUS MEMBRANE
Moist lining of digestive, respiratory, reproductive, and urinary tracts
MYALGIA
Muscle aches
MYOCARDIAL
Pertaining to the heart muscle
MYOCARDIAL INFARCTION
Heart attack
N
NASOGASTRIC TUBE
Tube placed in the nose, reaching to the stomach
NCI
The National Cancer Institute
NECROSIS
Death of tissue
NEOPLASIA/NEOPLASM
Tumor, may be benign or malignant
NEUROBLASTOMA
A cancer of nerve tissue
NEUROLOGICAL
Pertaining to the nervous system
NEUTROPENIA
Decrease in the main part of the white blood cells
NIH
The National Institutes of Health
NON-INVASIVE
Not breaking, cutting, or entering the skin
NOSOCOMIAL
Acquired in the hospital
O
OCCLUSION
Closing; blockage; obstruction
ONCOLOGY
The study of tumors or cancer
OPHTHALMIC
Pertaining to the eye
OPTIMAL
Best, most favorable or desirable
ORAL ADMINISTRATION
By mouth
ORTHOPEDIC
Pertaining to the bones
OSTEOPETROSIS
Rare bone disorder characterized by dense bone
OSTEOPOROSIS
Softening of the bones
OVARIES
Female sex glands
P
PARENTERAL
Given by injection
PATENCY
Condition of being open
PATHOGENESIS
Development of a disease or unhealthy condition
PER OS (PO)
By mouth
PER OS (PO)
By mouth
PERCUTANEOUS
Through the skin
PERIPHERAL
Not central
PHARMACOKINETICS
The study of the way the body absorbs, distributes, and gets rid of a drug
PHASE I
First phase of study of a new drug in humans to determine action, safety, and proper dosing
PHASE II
Second phase of study of a new drug in humans, intended to gather information about safety and effectiveness of the drug for certain uses
PHASE III
Large-scale studies to confirm and expand information on safety and effectiveness of new drug for certain uses, and to study common side effects
PHASE IV
Studies done after the drug is approved by the FDA, especially to compare it to standard care or to try it for new uses
PHLEBITIS
Irritation or inflammation of the vein
PLACEBO
An inactive substance; a pill/liquid that contains no medicine
PLACEBO EFFECT
Improvement seen with giving subjects a placebo, though it contains no active drug/treatment
PLATELETS
Small particles in the blood that help with clotting
POTENTIAL
Possible
POTENTIATE
Increase or multiply the effect of a drug or toxin (poison) by giving another drug or toxin at the same time (sometimes an unintentional result)
POTENTIATOR
An agent that helps another agent work better
PRENATAL
Before birth
PRN
As needed
PROGNOSIS
Outlook, probable outcomes
PRONE
Lying on the stomach
PROPHYLAXIS
A drug given to prevent disease or infection
PROSPECTIVE STUDY
Study following patients forward in time
PROSTHESIS
Artificial part, most often limbs, such as arms or legs
PROTOCOL
Plan of study
PROXIMAL
Closer to the center of the body, away from the end
PULMONARY
Pertaining to the lungs
Q
QD
Every day, daily
QID
Four times a day
R
RADIATION THERAPY
X-ray or cobalt treatment